Apoptosis in a Neonatal Rat Model of Cerebral Hypoxia-Ischemia
نویسندگان
چکیده
منابع مشابه
Apoptosis in a neonatal rat model of cerebral hypoxia-ischemia.
BACKGROUND AND PURPOSE The mechanisms of excitotoxic cell death in cerebral ischemia are poorly understood. In addition to necrosis, apoptotic cell death may occur. The purpose of this study was to determine whether an established model of cerebral hypoxia-ischemia in the neonatal rat demonstrates any features of apoptosis. METHODS Seven-day-old neonatal rats underwent bilateral, permanent ca...
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Ocular dominance plasticity (ODP) following monocular deprivation (MD) is a model of activity-dependent neural plasticity that is restricted to an early critical period regulated by maturation of inhibition. Unique developmental plasticity mechanisms may improve outcomes following early brain injury. Our objective was to determine the effects of neonatal cerebral hypoxia-ischemia (HI) on ODP. T...
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BACKGROUND AND PURPOSE Osteopontin (OPN) is neuroprotective in ischemic brain injuries in adult experimental models; therefore, we hypothesized that OPN would provide neuroprotection and improve long-term neurological function in the immature brain after hypoxic-ischemic (HI) injury. METHODS HI was induced by unilateral ligation of the right carotid artery followed by hypoxia (8% O(2) for 2 h...
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ژورنال
عنوان ژورنال: Stroke
سال: 1998
ISSN: 0039-2499,1524-4628
DOI: 10.1161/01.str.29.12.2622